2016

Azmitia EC, Saccomano ZT, Alzoobaee MF, Boldrini M, Whitaker-Azmitia PM. Persistent Angiogenesis in the Autism Brain: An Immunocytochemical Study of Postmortem Cortex, Brainstem and Cerebellum. J Autism Dev Disord. 2016 Apr;46(4):1307-18. doi: 10.1007/s10803-015-2672-6. PMID: 26667147 PMCID: PMC4836621.

Casanova MF, Sokhadze E, Opris I, Wang Y, Li X. Autism spectrum disorders: linking neuropathological findings to treatment with transcranial magnetic stimulation. Acta Paediatr. 2015 Apr;104(4):346-55. doi: 10.1111/apa.12943. Review. PMID: 25626149.

Hashemi E, Ariza J, Rogers H, Noctor SC, Martínez-Cerdeño V. The Number of Parvalbumin-Expressing Interneurons Is Decreased in the Medial Prefrontal Cortex in Autism. Cereb Cortex. 2016 Feb 27. pii: bhw021. PMID: 26922658.

Werling DM, Parikshak NN, Geschwind DH. Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders. Nat Commun. 2016 Feb 19;7:10717. doi: 10.1038/ncomms10717. PMID: 26892004; PMCID: PMC4762891.

Hutsler JJ, Casanova MF. Review: Cortical construction in autism spectrum disorder: columns, connectivity and the subplate. Neuropathol Appl Neurobiol. 2016 Feb;42(2):115-34. doi: 10.1111/nan.12227. Epub 2015 May 2. Review. PMID: 25630827.

Zhang Y, Hodgson NW, Trivedi MS, Abdolmaleky HM, Fournier M, Cuenod M, Do KQ, Deth RC. Decreased Brain Levels of Vitamin B12 in Aging, Autism and Schizophrenia. PLoS One. 2016 Jan 22;11(1):e0146797. doi:10.1371/journal.pone.0146797. eCollection 2016. PMID: 26799654; PMCID: PMC4723262.

2015

Crawford JD, Chandley MJ, Szebeni K, Szebeni A, Waters B, Ordway GA. Elevated GFAP Protein in Anterior Cingulate Cortical White Matter in Males With Autism Spectrum Disorder. Autism Res. 2015 Dec;8(6):649-57. doi: 10.1002/aur.1480. Epub 2015 Apr 6. PMID: 25846779.

Stamova B, Ander BP, Barger N, Sharp FR, Schumann CM. Specific Regional and Age-Related Small Noncoding RNA Expression Patterns Within Superior Temporal Gyrus of Typical Human Brains Are Less Distinct in Autism Brains. J Child Neurol. 2015 Dec;30(14):1930-46. doi: 10.1177/0883073815602067. Epub 2015 Sep 8. PMID: 26350727 PMCID: PMC4647182.

D’Gama AM, Pochareddy S, Li M, Jamuar SS, Reiff RE, Lam AT, Sestan N, Walsh CA. Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms. Neuron. 2015 Dec 2;88(5):910-7. doi: 10.1016/j.neuron.2015.11.009. PMID: 26637798 PMCID: PMC4672379.

Hampson DR, Blatt GJ. Autism spectrum disorders and neuropathology of the cerebellum. Front Neurosci. 2015 Nov 6;9:420. doi: 10.3389/fnins.2015.00420. eCollection 2015. Review. PMID: 26594141; PMCID: PMC4635214.

Wegiel J, Flory M, Schanen NC, Cook EH, Nowicki K, Kuchna I, Imaki H, Ma SY, Wegiel J, London E, Casanova MF, Wisniewski T, Brown WT. Significant neuronal soma volume deficit in the limbic system in subjects with 15q11.2-q13 duplications. Acta Neuropathol Commun. 2015 Oct 13;3:63. doi: 10.1186/s40478-015-0241-z. PMID: 26463344; PMCID: PMC4603300.

Mor M, Nardone S, Sams DS, Elliott E. Hypomethylation of miR-142 promoter and upregulation of microRNAs that target the oxytocin receptor gene in the autism prefrontal cortex. Mol Autism. 2015 Aug 14;6:46. doi: 10.1186/s13229-015-0040-1. eCollection 2015. PMID: 26273428; PMCID: PMC4535255.

McKavanagh R, Buckley E, Chance SA. Wider minicolumns in autism: a neural basis for altered processing? Brain. 2015 Jul;138(Pt 7):2034-45. doi: 10.1093/brain/awv110. Epub 2015 May 1. PMID: 25935724.

Ander BP, Barger N, Stamova B, Sharp FR, Schumann CM. Atypical miRNA expression in temporal cortex associated with dysregulation of immune, cell cycle, and other pathways in autism spectrum disorders. Mol Autism. 2015 Jun 19;6:37. doi: 10.1186/s13229-015-0029-9. eCollection 2015. PMID: 26146533; PMCID: PMC4491207.

Barger N, Sheley MF, Schumann CM. Stereological study of pyramidal neurons in the human superior temporal gyrus from childhood to adulthood. J Comp Neurol. 2015 May 1;523(7):1054-72. doi: 10.1002/cne.23707. Epub 2015 Feb 17. PMID:25556320; PMCID: PMC4359029.

Hu VW, Sarachana T, Sherrard RM, Kocher KM. Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism. Mol Autism. 2015 May 13;6:7. doi: 10.1186/2040-2392-6-7. eCollection 2015. PMID: 26056561; PMCID: PMC4459681.

Nicolini C, Ahn Y, Michalski B, Rho JM, Fahnestock M. Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid. Acta Neuropathol Commun. 2015 Jan 20;3:3. doi: 10.1186/s40478-015-0184-4. PMID: 25627160; PMCID: PMC4307681.

2014

Gupta S, Ellis SE, Ashar FN, Moes A, Bader JS, Zhan J, West AB, Arking DE. Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism. Nat Commun. 2014 Dec 10;5:5748. doi:10.1038/ncomms6748. PMID: 25494366; PMCID: PMC4270294.

Irimia M, Weatheritt RJ, Ellis JD, Parikshak NN, Gonatopoulos-Pournatzis T, Babor M, Quesnel-Vallières M, Tapial J, Raj B, O’Hanlon D, Barrios-Rodiles M, Sternberg MJ, Cordes SP, Roth FP, Wrana JL, Geschwind DH, Blencowe BJ. A highly conserved program of neuronal microexons is misregulated in autistic brains. Cell. 2014 Dec 18;159(7):1511-23. doi: 10.1016/j.cell.2014.11.035. PMID: 25525873; PMCID: PMC4390143.

Casanova EL, Casanova MF. Genetics studies indicate that neural induction and early neuronal maturation are disturbed in autism. Front Cell Neurosci. 2014 Nov 19;8:397. doi: 10.3389/fncel.2014.00397. eCollection 2014. PMID: 25477785; PMCID: PMC4237056.

Wegiel J, Flory M, Kuchna I, Nowicki K, Ma SY, Imaki H, Wegiel J, Cohen IL, London E, Wisniewski T, Brown WT. Stereological study of the neuronal number and volume of 38 brain subdivisions of subjects diagnosed with autism reveals significant alterations restricted to the striatum, amygdala and cerebellum. Acta Neuropathol Commun. 2014 Sep 18;2:141. doi: 10.1186/s40478-014-0141-7. PMID: 25231243; PMCID: PMC4177256.

Nardone S, Sams DS, Reuveni E, Getselter D, Oron O, Karpuj M, Elliott E. DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways. Transl Psychiatry. 2014 Sep 2;4:e433. doi:10.1038/tp.2014.70. PMID: 25180572; PMCID: PMC4203003.

Tang G, Gudsnuk K, Kuo SH, Cotrina ML, Rosoklija G, Sosunov A, Sonders MS, Kanter E, Castagna C, Yamamoto A, Yue Z, Arancio O, Peterson BS, Champagne F, Dwork AJ, Goldman J, Sulzer D. Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits. Neuron. 2014 Sep 3;83(5):1131-43. doi: 10.1016/j.neuron.2014.07.040. Epub 2014 Aug 21. Erratum in: Neuron. 2014 Sep 17;83(6):1482. PMID: 25155956; PMCID: PMC4159743.

Uppal N, Wicinski B, Buxbaum JD, Heinsen H, Schmitz C, Hof PR. Neuropathology of the anterior midcingulate cortex in young children with autism. J Neuropathol Exp Neurol. 2014 Sep;73(9):891-902. doi: 10.1097/NEN.0000000000000108. PMID: 25101703.

Smith RM, Banks W, Hansen E, Sadee W, Herman GE. Family-based clinical associations and functional characterization of the serotonin 2A receptor gene (HTR2A) in autism spectrum disorder. Autism Res. 2014 Aug;7(4):459-67. doi:10.1002/aur.1383. Epub 2014 Apr 17. PMID: 24753316; PMCID: PMC4134733.

Fatemi SH, Reutiman TJ, Folsom TD, Rustan OG, Rooney RJ, Thuras PD. Downregulation of GABAA receptor protein subunits α6, β2, δ, ε, γ2, θ, and ρ2 in superior frontal cortex of subjects with autism. J Autism Dev Disord. 2014 Aug;44(8):1833-45. doi: 10.1007/s10803-014-2078-x. PMID: 24668190.

Ben-David E, Shohat S, Shifman S. Allelic expression analysis in the brain suggests a role for heterogeneous insults affecting epigenetic processes in autism spectrum disorders. Hum Mol Genet. 2014 Aug 1;23(15):4111-24. doi:10.1093/hmg/ddu128. Epub 2014 Mar 21. PMID: 24659497.

Skafidas E, Testa R, Zantomio D, Chana G, Everall IP, Pantelis C. Predicting the diagnosis of autism spectrum disorder using gene pathway analysis. Mol Psychiatry. 2014 Apr;19(4):504-10. doi: 10.1038/mp.2012.126. Epub 2012 Sep 11. PMID: 22965006; PMCID: PMC3966080.

Wegiel J, Flory M, Kuchna I, Nowicki K, Ma SY, Imaki H, Wegiel J, Cohen IL, London E, Brown WT, Wisniewski T. Brain-region-specific alterations of the trajectories of neuronal volume growth throughout the lifespan in autism. Acta Neuropathol Commun. 2014 Mar 10;2:28. doi: 10.1186/2051-5960-2-28. PMID: 24612906; PMCID: PMC4007529.

Stoner R, Chow ML, Boyle MP, Sunkin SM, Mouton PR, Roy S, Wynshaw-Boris A, Colamarino SA, Lein ES, Courchesne E. Patches of disorganization in the neocortex of children with autism. N Engl J Med. 2014 Mar 27;370(13):1209-19. doi:10.1056/NEJMoa1307491. PMID: 24670167; PMCID: PMC4499461.

Uppal N, Gianatiempo I, Wicinski B, Schmeidler J, Heinsen H, Schmitz C, Buxbaum JD, Hof PR. Neuropathology of the posteroinferior occipitotemporal gyrus in children with autism. Mol Autism. 2014 Feb 24;5(1):17. doi:10.1186/2040-2392-5-17. PMID: 24564936; PMCID: PMC3938306.

Zhubi A, Chen Y, Dong E, Cook EH, Guidotti A, Grayson DR. Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. Transl Psychiatry. 2014 Jan 21;4:e349. doi: 10.1038/tp.2013.123. PMID: 24448211; PMCID:PMC3905233.

Edmonson C, Ziats MN, Rennert OM. Altered glial marker expression in autistic post-mortem prefrontal cortex and cerebellum. Mol Autism. 2014 Jan 10;5(1):3. doi: 10.1186/2040-2392-5-3. PMID: 24410870; PMCID: PMC3914711.

2013

Zhu L, Wang X, Li XL, Towers A, Cao X, Wang P, Bowman R, Yang H, Goldstein J, Li YJ, Jiang YH. Epigenetic dysregulation of SHANK3 in brain tissues from individuals with autism spectrum disorders. Hum Mol Genet. 2014 Mar 15;23(6):1563-78. doi: 10.1093/hmg/ddt547. Epub 2013 Nov 1. PMID:24186872; PMCID: PMC3929093.

Casanova MF, El-Baz AS, Kamat SS, Dombroski BA, Khalifa F, Elnakib A, Soliman A, Allison-McNutt A, Switala AE. Focal cortical dysplasias in autism spectrum disorders. Acta Neuropathol Commun. 2013 Oct 11;1:67. doi: 10.1186/2051-5960-1-67. PMID: 24252498; PMCID: PMC3893372.

Eran A, Li JB, Vatalaro K, McCarthy J, Rahimov F, Collins C, Markianos K, Margulies DM, Brown EN, Calvo SE, Kohane IS, Kunkel LM. Comparative RNA editing in autistic and neurotypical cerebella. Mol Psychiatry. 2013 Sep;18(9):1041-8. doi: 10.1038/mp.2012.118. Epub 2012 Aug 7. PMID: 22869036; PMCID: PMC3494744.

Oblak A, Gibbs TT, Blatt GJ. Reduced serotonin receptor subtypes in a limbic and a neocortical region in autism. Autism Res. 2013 Dec;6(6):571-83. doi: 10.1002/aur.1317. Epub 2013 Jul 24. PMID: 23894004; PMCID: PMC3859849.

Fatemi SH, Folsom TD, Kneeland RE, Yousefi MK, Liesch SB, Thuras PD. Impairment of fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling and its downstream cognates ras-related C3 botulinum toxin substrate 1, amyloid beta A4 precursor protein, striatal-enriched protein tyrosine phosphatase, and homer 1, in autism: a postmortem study in cerebellar vermis and superior frontal cortex. Mol Autism. 2013 Jun 26;4(1):21. doi: 10.1186/2040-2392-4-21. PMID: 23803181; PMCID: PMC3702477.

Tang G, Gutierrez Rios P, Kuo SH, Akman HO, Rosoklija G, Tanji K, Dwork A, Schon EA, Dimauro S, Goldman J, Sulzer D. Mitochondrial abnormalities in temporal lobe of autistic brain. Neurobiol Dis. 2013 Jun;54:349-61. doi: 10.1016/j.nbd.2013.01.006. Epub 2013 Jan 17. PMID: 23333625; PMCID: PMC3959772.

Lahiri DK, Sokol DK, Erickson C, Ray B, Ho CY, Maloney B. Autism as early neurodevelopmental disorder: evidence for an sAPPα-mediated anabolic pathway. Front Cell Neurosci. 2013 Jun 21;7:94. doi: 10.3389/fncel.2013.00094. eCollection 2013. PMID: 23801940; PMCID: PMC3689023.

Vardarajan BN, Eran A, Jung JY, Kunkel LM, Wall DP. Haplotype structure enables prioritization of common markers and candidate genes in autism spectrum disorder. Transl Psychiatry. 2013 May 28;3:e262. doi: 10.1038/tp.2013.38. PMID: 23715297; PMCID: PMC3669925.

Sarachana T, Hu VW. Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder. Mol Autism. 2013 May 22;4(1):14. doi: 10.1186/2040-2392-4-14. PMID: 23697635; PMCID: PMC3665583.

Jacot-Descombes S, Uppal N, Wicinski B, Santos M, Schmeidler J, Giannakopoulos P, Heinsen H, Schmitz C, Hof PR. Decreased pyramidal neuron size in Brodmann areas 44 and 45 in patients with autism. Acta Neuropathol. 2012 Jul;124(1):67-79. doi: 10.1007/s00401-012-0976-6. Epub 2012 Mar 31. Erratum in: Acta Neuropathol. 2012 Jul;124(1):81. Heinsein, Helmut [corrected to Heinsen, Helmut]. PMID: 22467063.

Wegiel J, Frackowiak J, Mazur-Kolecka B, Schanen NC, Cook EH Jr, Sigman M, Brown WT, Kuchna I, Wegiel J, Nowicki K, Imaki H, Ma SY, Chauhan A, Chauhan V, Miller DL, Mehta PD, Flory M, Cohen IL, London E, Reisberg B, de Leon MJ, Wisniewski T. Abnormal intracellular accumulation and extracellular Aβ deposition in idiopathic and Dup15q11.2-q13 autism spectrum disorders. PLoS One. 2012;7(5):e35414. doi: 10.1371/journal.pone.0035414. Epub 2012 May 2. PMID: 22567102; PMCID: PMC3342283.

Wegiel J, Schanen NC, Cook EH, Sigman M, Brown WT, Kuchna I, Nowicki K, Wegiel J, Imaki H, Ma SY, Marchi E, Wierzba-Bobrowicz T, Chauhan A, Chauhan V, Cohen IL, London E, Flory M, Lach B, Wisniewski T. Differences between the pattern of developmental abnormalities in autism associated with duplications 15q11.2-q13 and idiopathic autism. J Neuropathol Exp Neurol. 2012 May;71(5):382-97. doi: 10.1097/NEN.0b013e318251f537. PMID: 22487857; PMCID: PMC3612833.

Wegiel J, Kuchna I, Nowicki K, Imaki H, Wegiel J, Ma SY, Azmitia EC, Banerjee P, Flory M, Cohen IL, London E, Brown WT, Komich Hare C, Wisniewski T. Contribution of olivofloccular circuitry developmental defects to atypical gaze in autism. Brain Res. 2013 May 28;1512:106-22. doi:10.1016/j.brainres.2013.03.037. Epub 2013 Apr 2. PMID: 23558308; PMCID: PMC3967119.

Chung K, Wallace J, Kim SY, Kalyanasundaram S, Andalman AS, Davidson TJ, Mirzabekov JJ, Zalocusky KA, Mattis J, Denisin AK, Pak S, Bernstein H, Ramakrishnan C, Grosenick L, Gradinaru V, Deisseroth K. Structural and molecular interrogation of intact biological systems. Nature. 2013 May 16;497(7449):332-7. doi: 10.1038/nature12107. Epub 2013 Apr 10. PMID: 23575631; PMCID: PMC4092167.

Kerin T, Ramanathan A, Rivas K, Grepo N, Coetzee GA, Campbell DB. A noncoding RNA antisense to moesin at 5p14.1 in autism. Sci Transl Med. 2012 Apr 4;4(128):128ra40. doi: 10.1126/scitranslmed.3003479. PMID: 22491950.

Morgan JT, Chana G, Abramson I, Semendeferi K, Courchesne E, Everall IP. Abnormal microglial-neuronal spatial organization in the dorsolateral prefrontal cortex in autism. Brain Res. 2012 May 25;1456:72-81. doi: 10.1016/j.brainres.2012.03.036. Epub 2012 Mar 23. PMID: 22516109.

Ginsberg MR, Rubin RA, Natowicz MR. Patterning of regional gene expression in autism: new complexity. Sci Rep. 2013;3:1831. doi: 10.1038/srep01831. PMID: 23665920; PMCID: PMC3652084.

Muratore CR, Hodgson NW, Trivedi MS, Abdolmaleky HM, Persico AM, Lintas C, De la Monte S, Deth RC. Age-dependent decrease and alternative splicing of methionine synthase mRNA in human cerebral cortex and an accelerated decrease in autism. PLoS One. 2013;8(2):e56927. doi: 10.1371/journal.pone.0056927. Epub 2013 Feb 20. PMID: 23437274; PMCID: PMC3577685.

Pearson BL, Corley MJ, Vasconcellos A, Blanchard DC, Blanchard RJ. Heparan sulfate deficiency in autistic postmortem brain tissue from the subventricular zone of the lateral ventricles. Behav Brain Res. 2013 Apr 15;243:138-45. doi:10.1016/j.bbr.2012.12.062. Epub 2013 Jan 11. PMID: 23318464; PMCID: PMC3594061.

Ginsberg MR, Rubin RA, Natowicz MR. Patterning of regional gene expression in autism: new complexity. Sci Rep. 2013;3:1831. doi: 10.1038/srep01831. PMID: 23665920; PMCID: PMC3652084.

2012

Ginsberg MR, Rubin RA, Falcone T, Ting AH, Natowicz MR. Brain transcriptional and epigenetic associations with autism. PLoS One. 2012;7(9):e44736. doi: 10.1371/journal.pone.0044736. Epub 2012 Sep 12. PMID: 22984548; PMCID: PMC3440365.

Garcia KL, Yu G, Nicolini C, Michalski B, Garzon DJ, Chiu VS, Tongiorgi E, Szatmari P, Fahnestock M. Altered balance of proteolytic isoforms of pro-brain-derived neurotrophic factor in autism. J Neuropathol Exp Neurol. 2012 Apr;71(4):289-97. doi: 10.1097/NEN.0b013e31824b27e4. PMID: 22437340; PMCID: PMC3419254.

Chow ML, Pramparo T, Winn ME, Barnes CC, Li HR, Weiss L, Fan JB, Murray S, April C, Belinson H, Fu XD, Wynshaw-Boris A, Schork NJ, Courchesne E. Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages. PLoS Genet. 2012;8(3):e1002592. doi: 10.1371/journal.pgen.1002592. Epub 2012 Mar 22. PMID: 22457638; PMCID: PMC3310790.

Shulha HP, Cheung I, Whittle C, Wang J, Virgil D, Lin CL, Guo Y, Lessard A, Akbarian S, Weng Z. Epigenetic signatures of autism: trimethylated H3K4 landscapes in prefrontal neurons. Arch Gen Psychiatry. 2012 Mar;69(3):314-24. doi: 10.1001/archgenpsychiatry.2011.151. Epub 2011 Nov 7. PMID: 22065254.

Weidenheim KM, Escobar A, Rapin I. Brief report: life history and neuropathology of a gifted man with Asperger syndrome. J Autism Dev Disord. 2012 Mar;42(3):460-7. doi: 10.1007/s10803-011-1259-0. PMID: 21516432.

Mukaetova-Ladinska EB, Perry E, Baron M, Povey C; Autism Ageing Writing Group. Ageing in people with autistic spectrum disorder. Int J Geriatr Psychiatry. 2012 Feb;27(2):109-18. doi: 10.1002/gps.2711. Epub 2011 Apr 27. Review. PMID:21538534.